Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis

Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis

The involvement of GRK2 in cancer cell proliferation and its counter-regulation of p53 have been suggested in breast cancer even if the underlying mechanism has not yet been elucidated. Furthermore, the possibility to pharmacologically inhibit GRK2 to delay cancer cell proliferation has never been e...

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Bibliographic Details
Main Authors: Jessica Gambardella, Antonella Fiordelisi, Gaetano Santulli, Michele Ciccarelli, Federica Andrea Cerasuolo, Marina Sala, Eduardo Sommella, Pietro Campiglia, Maddalena Illario, Guido Iaccarino, Daniela Sorriento
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
GRK2
p53
thyroid cancer
mitochondrial apoptosis
GRK2 inhibition
Online Access:https://www.mdpi.com/2072-6694/12/12/3530

Internet

https://www.mdpi.com/2072-6694/12/12/3530

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