Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract
Monoclonal antibodies targeting the regulatory immune “checkpoint” receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regu...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2017-11-01
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Series: | Frontiers in Immunology |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01547/full |