Misguided transcriptional elongation causes mixed lineage leukemia.

Misguided transcriptional elongation causes mixed lineage leukemia.

Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we...

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Bibliographic Details
Main Authors: Dorothee Mueller, María-Paz García-Cuéllar, Christian Bach, Sebastian Buhl, Emanuel Maethner, Robert K Slany
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2774266?pdf=render

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http://europepmc.org/articles/PMC2774266?pdf=render

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