Mapping of protein-protein interactions of E. coli RNA polymerase with microfluidic mechanical trapping.

The biophysical details of how transcription factors and other proteins interact with RNA polymerase are of great interest as they represent the nexus of how structure and function interact to regulate gene expression in the cell. We used an in vitro microfluidic approach to map interactions between...

Full description

Bibliographic Details
Main Authors: Steven R Bates, Stephen R Quake
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958368?pdf=render