Dysfunction of the Blood-Brain Barrier—A Key Step in Neurodegeneration and Dementia

Dysfunction of the Blood-Brain Barrier—A Key Step in Neurodegeneration and Dementia

The vascular endothelium in the brain is an essential part of the blood-brain-barrier (BBB) because of its very tight structure to secure a functional and molecular separation of the brain from the rest of the body and to protect neurons from pathogens and toxins. Impaired transport of metabolites a...

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Bibliographic Details
Main Authors: Christian R. Noe, Marion Noe-Letschnig, Patricia Handschuh, Chiara Anna Noe, Rupert Lanzenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
blood-brain barrier (BBB)
GLUT1
dementia
Alzheimer’s disease
amyloid precursor protein (APP)
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00185/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00185/full

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