Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation

Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation

BackgroundBoth chronic hypoxia (CH) and long-term chronic intermittent hypoxia (CIH) exposure lead to right ventricular hypertrophy (RVH). Weight loss is an effective intervention to improve cardiac function and energy metabolism in cardiac hypertrophy. Likewise, caloric restriction (CR) also plays...

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Bibliographic Details
Main Authors: Karen Flores, Patricia Siques, Julio Brito, Stefany Ordenes, Karem Arriaza, E. Pena, Fabiola León-Velarde, Rosario López, Ángel L. López de Pablo, Silvia Arribas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
right ventricle hypertrophy
hypobaric hypoxia
AMPK
body weight
high altitude
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00342/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00342/full

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