Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function

Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function

Ly6Chi monocyte tissue infiltrates play important roles in mediating local inflammation, bacterial elimination and resolution during sepsis and inflammatory bowel disease (IBD). Yet, the immunoregulatory pathways dictating their activity remain poorly understood. COMMD family proteins are emerging a...

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Bibliographic Details
Main Authors: Odelia Mouhadeb, Shani Ben Shlomo, Keren Cohen, Inbal Farkash, Shlomo Gruber, Nitsan Maharshak, Zamir Halpern, Ezra Burstein, Nathan Gluck, Chen Varol
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
COMMD10
Ly6Chi monocytes
inflammasome
systemic inflammation
colitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02623/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02623/full

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