Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis.

BACKGROUND: Atherosclerosis is a common multifactorial disease resulting from an interaction between susceptibility genes and environmental factors. The causative genes that contribute to atherosclerosis are elusive. Based on recent findings with a Wistar rat model, we speculated that the gamma-secr...

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Bibliographic Details
Main Authors: Karen M J van Loo, Tim Dejaegere, Martine van Zweeden, Jessica E van Schijndel, Cisca Wijmenga, Mieke D Trip, Gerard J M Martens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2573958?pdf=render