Hypoxic state and glycolysis as a possible anticancer therapeutic target

Hypoxic state and glycolysis as a possible anticancer therapeutic target

In this review the role of hypoxia and glycolysis in tumor expansion is described. Experimental results demonstrate that glycolysis functions in tumor cells are not restrict only energy supply. Glycolysis stimulates the activity of transcription factor HIF-1α. Assemble of HIF1α and protein ARNT stim...

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Bibliographic Details
Main Author: V. A. Koblyakov
Format: Article
Language:Russian
Published: ABV-press 2015-06-01
Series:Uspehi Molekulârnoj Onkologii
Subjects:
glycolysis
hypoxia
hif-1α
glycolysis inhibitors
hexokinase ii
2‑deoxyglucose
lactate
lonidamine
dichloroacetate
monocarboxylate transporter
invasion
metastasis
Online Access:https://umo.abvpress.ru/jour/article/view/27

Internet

https://umo.abvpress.ru/jour/article/view/27

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