LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1

LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1

Summary: Cytosolic proteins are required for regulation of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (Nox) isozymes. Here we show that Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1), as a Nox4 cytosolic regulator, mediates lipopolysaccharide (LPS)-induced H2O2 generat...

Full description

Bibliographic Details
Main Authors: Jung-Yeon Yoo, Dae Ryong Cha, Borim Kim, Eun Jung An, Sae Rom Lee, Jin Joo Cha, Young Sun Kang, Jung Yeon Ghee, Jee Young Han, Yun Soo Bae
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
Nox4
SH3YL1
H2O2, LPS
sepsis
AKI
TLR4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312341

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312341

Similar Items