Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms....

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Bibliographic Details
Main Authors: Anna V. Golubeva, Susan A. Joyce, Gerard Moloney, Aurelijus Burokas, Eoin Sherwin, Silvia Arboleya, Ian Flynn, Dmitry Khochanskiy, Angela Moya-Pérez, Veronica Peterson, Kieran Rea, Kiera Murphy, Olga Makarova, Sergey Buravkov, Niall P. Hyland, Catherine Stanton, Gerard Clarke, Cormac G.M. Gahan, Timothy G. Dinan, John F. Cryan
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
Autism
BTBR mouse
Gut microbiota
Intestinal permeability
Intestinal transit
Bile acids
Serotonin
Tryptophan
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303742

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http://www.sciencedirect.com/science/article/pii/S2352396417303742

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