FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response

FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response

Alveolar Macrophages play a key role in the development of a robust adaptive immune response against the agent of Tuberculosis (TB), Mycobacterium tuberculosis (M.tb). However, macrophage response is often hampered by the production of IL-10, a potent suppressor of the host immune response. The secr...

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Bibliographic Details
Main Authors: Rania Bouzeyen, Meriam Haoues, Mohamed-Ridha Barbouche, Ramandeep Singh, Makram Essafi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
macrophages
FOXO3
IL-10
M1/Th1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02922/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02922/full

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