Inhibition of Hippocampal Matrix Metalloproteinase-3 and -9 Disrupts Spatial Memory

Memory consolidation requires synaptic reconfiguration dependent upon extracellular matrix (ECM) molecules interacting with cell adhesion molecules. Matrix metalloproteinase (MMP) activity is responsible for transient alterations in the ECM that may be prerequisite to hippocampal-dependent learnin...

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Bibliographic Details
Main Authors: John W. Wright, Travis E. Brown, Joseph W. Harding
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2007/73813