Analysis of Δ12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304

Analysis of Δ12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304

Thraustochytrids are known to synthesize PUFAs such as docosahexaenoic acid (DHA). Accumulating evidence suggests the presence of two synthetic pathways of PUFAs in thraustochytrids: the polyketide synthase-like (PUFA synthase) and desaturase/elongase (standard) pathways. It remains unclear whether...

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Bibliographic Details
Main Authors: Takanori Matsuda, Keishi Sakaguchi, Rie Hamaguchi, Takumi Kobayashi, Eriko Abe, Yoichiro Hama, Masahiro Hayashi, Daiske Honda, Yuji Okita, Shinichi Sugimoto, Nozomu Okino, Makoto Ito
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
polyunsaturated fatty acid
polyketide synthase-like (PUFA synthase) pathway
desaturase/elongase (standard) pathway
homologous recombination
targeted gene disruption
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317144

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http://www.sciencedirect.com/science/article/pii/S0022227520317144

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