HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer

HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer

Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative re...

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Bibliographic Details
Main Authors: Dessislava N. Mladenova, Jane E. Dahlstrom, Phuong N. Tran, Fahad Benthani, Elaine G. Bean, Irvin Ng, Laurent Pangon, Nicola Currey, Maija R. J. Kohonen-Corish
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
HIF1α
MIF
AHR
E-cadherin
Sulindac
Colon inflammation
Online Access:http://dmm.biologists.org/content/8/9/1093

Internet

http://dmm.biologists.org/content/8/9/1093

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