Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.

Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.

Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left v...

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Bibliographic Details
Main Authors: Matthew J Campen, Michael L Paffett, E Sage Colombo, Selita N Lucas, Tamara Anderson, Monique Nysus, Jeffrey P Norenberg, Ben Gershman, Jacob Hesterman, Jack Hoppin, Monte Willis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4014601?pdf=render

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http://europepmc.org/articles/PMC4014601?pdf=render

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