Toll-like receptor-9 stimulated plasmacytoid dendritic cell precursors suppress autoimmune neuroinflammation in a murine model of multiple sclerosis

Toll-like receptor-9 stimulated plasmacytoid dendritic cell precursors suppress autoimmune neuroinflammation in a murine model of multiple sclerosis

Abstract Early innate education of hematopoietic progenitors within the bone marrow (BM) stably primes them for either trained immunity or instead immunoregulatory functions. We herein demonstrate that in vivo or in vitro activation within the BM via Toll-like receptor-9 generates a population of pl...

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Bibliographic Details
Main Authors: Hélène Letscher, Viviane A. Agbogan, Sarantis Korniotis, Pauline Gastineau, Emmanuel Tejerina, Christophe Gras, Jérôme Mégret, Alison Moe, William R. Drobyski, Flora Zavala
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84023-0

Internet

https://doi.org/10.1038/s41598-021-84023-0

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