Early, On-Treatment Levels and Dynamic Changes of Genomic Instability in Circulating Tumor DNA Predict Response to Treatment and Outcome in Metastatic Breast Cancer Patients

Early, On-Treatment Levels and Dynamic Changes of Genomic Instability in Circulating Tumor DNA Predict Response to Treatment and Outcome in Metastatic Breast Cancer Patients

Background: Circulating tumor DNA (ctDNA) offers high sensitivity and specificity in metastatic cancer. However, many ctDNA assays rely on specific mutations in recurrent genes or require the sequencing of tumor tissue, difficult to do in a metastatic disease. The purpose of this study was to define...

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Bibliographic Details
Main Authors: Adriana Aguilar-Mahecha, Josiane Lafleur, Susie Brousse, Olga Savichtcheva, Kimberly A. Holden, Nathan Faulkner, Graham McLennan, Taylor J. Jensen, Mark Basik
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
ctDNA
metastasis
whole-genome sequencing
plasma
breast cancer
genomic instability
Online Access:https://www.mdpi.com/2072-6694/13/6/1331

Internet

https://www.mdpi.com/2072-6694/13/6/1331

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