A Next-Generation Sequencing-Based Platform for Quantitative Detection of Hepatitis B Virus Pre-S Mutants in Plasma of Hepatocellular Carcinoma Patients

A Next-Generation Sequencing-Based Platform for Quantitative Detection of Hepatitis B Virus Pre-S Mutants in Plasma of Hepatocellular Carcinoma Patients

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Early diagnosis and treatment of HCC remain a key goal for improving patient survival. Chronic hepatitis B virus (HBV) infection is a major risk factor for HCC development. Pre-S mutants harboring deletions...

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Bibliographic Details
Main Authors: Chiao-Fang Teng, Hsi-Yuan Huang, Tsai-Chung Li, Woei-Cherng Shyu, Han-Chieh Wu, Chien-Yu Lin, Ih-Jen Su, Long-Bin Jeng
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Simple Kappa Coefficient
Cancer-related Death Worldwide
HBV E Antigen (HBeAg)
HBV Surface Antigen (HBsAg)
Low Detection Sensitivity
Online Access:https://doi.org/10.1038/s41598-018-33051-4

Internet

https://doi.org/10.1038/s41598-018-33051-4

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