Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors

Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors

Abstract Non‐tuberculous mycobacterium (NTM) infections, such as those caused by Mycobacterium abscessus, are increasing globally. Due to their intrinsic drug resistance, M. abscessus pulmonary infections are often difficult to cure using standard chemotherapy. We previously demonstrated that a pipe...

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Bibliographic Details
Main Authors: Dr. Jérôme deRuyck, Dr. Christian Dupont, Elodie Lamy, Dr. Vincent Le Moigne, Prof. Christophe Biot, Dr. Yann Guérardel, Prof. Jean‐Louis Herrmann, Dr. Mickaël Blaise, Dr. Stanislas Grassin‐Delyle, Dr. Laurent Kremer, Dr. Faustine Dubar
Format: Article
Language:English
Published: Wiley-VCH 2020-03-01
Series:ChemistryOpen
Subjects:
mycobacterium abscessus
molecular modeling
structure-activity relationship
phenotypic screening
piperidinol derivatives
Online Access:https://doi.org/10.1002/open.202000042

Internet

https://doi.org/10.1002/open.202000042

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