PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.

PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.

Resistance to apoptosis is a paramount issue in the treatment of Glioblastoma (GBM). We show that targeting PARP by the small molecule inhibitors, Olaparib (AZD-2281) or PJ34, reduces proliferation and lowers the apoptotic threshold of GBM cells in vitro and in vivo.The sensitizing effects of PARP i...

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Bibliographic Details
Main Authors: Georg Karpel-Massler, Fresia Pareja, Pascaline Aimé, Chang Shu, Lily Chau, Mike-Andrew Westhoff, Marc-Eric Halatsch, John F Crary, Peter Canoll, Markus D Siegelin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4273972?pdf=render

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http://europepmc.org/articles/PMC4273972?pdf=render

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