Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation defects that are exacerbated under conditions of r...

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Bibliographic Details
Main Authors: Chen-Hua Chuang, Marsha D Wallace, Christian Abratte, Teresa Southard, John C Schimenti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2936539?pdf=render