Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Proteomics and bioinformatics are a useful combined technology for the characterization of protein expression level and modulation associated with the response to a drug and with its mechanism of action. The folate pathway represents an important target in the anticancer drugs therapy. In the presen...

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Bibliographic Details
Main Authors: Leda Severi, Lorena Losi, Sergio Fonda, Laura Taddia, Gaia Gozzi, Gaetano Marverti, Fulvio Magni, Clizia Chinello, Martina Stella, Jalid Sheouli, Elena I. Braicu, Filippo Genovese, Angela Lauriola, Chiara Marraccini, Alessandra Gualandi, Domenico D'Arca, Stefania Ferrari, Maria P. Costi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
pemetrexed
folate pathway
drug resistance
ovarian cancer
proteomics
mass spectrometry
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00454/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00454/full

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