Splicing heterogeneity: separating signal from noise
Abstract Single-cell analyses have revealed a tremendous variety among cells in the abundance and chemical composition of RNA. Much of this heterogeneity is due to alternative splicing by the spliceosome. Little is known about how many of the resulting isoforms are biologically functional or just pr...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-07-01
|
| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-018-1467-4 |