The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization

The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization

Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype. Our previous studies have shown that the interleukin-33/S...

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Bibliographic Details
Main Authors: Huadan Xu, Dong Li, Jiaoyan Ma, Yuanxin Zhao, Long Xu, Rui Tian, Yanan Liu, Liankun Sun, Jing Su
Format: Article
Language:English
Published: China Anti-Cancer Association 2021-02-01
Series:Cancer Biology & Medicine
Subjects:
il-33/st2
macrophage polarization
mitophagy
glucose metabolism
tumor microenvironment
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1778

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1778

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