CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets
Abstract Human cancers harbor substantial genetic, epigenetic, and transcriptional changes, only some of which drive oncogenesis at certain times during cancer evolution. Identifying the cancer-driver alterations amongst the vast swathes of “passenger” changes still remains a major challenge. Transp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-08-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-020-02118-9 |