Targeting SNHG3/miR-186-5p reverses the increased m6A level caused by platinum treatment through regulating METTL3 in esophageal cancer

Targeting SNHG3/miR-186-5p reverses the increased m6A level caused by platinum treatment through regulating METTL3 in esophageal cancer

Abstract Background Platinum-based chemotherapy is a mainstay for treating esophageal cancer patients. In this manuscript, we have provided clues for influence of platinum on overall m6A level and further investigated the potential regulatory mechanism. Methods qRT-PCR was used to measure SNHG3 and...

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Bibliographic Details
Main Authors: Mingxin Zhang, Minghua Bai, Li Wang, Ning Lu, Jia Wang, Rong Yan, Manli Cui, Honglin Yan, Lingmin Zhang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cancer Cell International
Subjects:
m6A level
METTL3
SNHG3
miR-186-5p
Platinum
Online Access:https://doi.org/10.1186/s12935-021-01747-9

Internet

https://doi.org/10.1186/s12935-021-01747-9

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