Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Clinical studies demonstrate that scopolamine, a non-selective muscarinic acetylcholine receptor (mAchR) antagonist, produces rapid therapeutic effects in depressed patients, and preclinical studies report that the actions of scopolamine require glutamate receptor activation and the mechanistic targ...

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Bibliographic Details
Main Authors: Andrea Navarria, Eric S. Wohleb, Bhavya Voleti, Kristie T. Ota, Sophie Dutheil, Ashley E. Lepack, Jason M. Dwyer, Manabu Fuchikami, Astrid Becker, Filippo Drago, Ronald S. Duman
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Glutamate
Neuronal silencing
Depression
Stress
Anhedonia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115002302

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115002302

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