APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

Regulatory B cells (Bregs) are immunosuppressive cells that modulate immune responses through multiple mechanisms. The signals required for the differentiation and activation of these cells remain still poorly understood. We have already shown that overexpression of A PRoliferation-Inducing Ligand (...

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Bibliographic Details
Main Authors: Cynthia M. Fehres, Nathalie O. van Uden, Nataliya G. Yeremenko, Leticia Fernandez, Gabriela Franco Salinas, Leonie M. van Duivenvoorde, Bertrand Huard, Jacques Morel, Hergen Spits, Michael Hahne, Dominique L. P. Baeten
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
APRIL
Immunoregulation
IgA
IL-10
inflammation
regulatory B cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01368/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01368/full

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