A validated high-resolution accurate mass LC-MS assay for quantitative determination of metoprolol and α-hydroxymetoprolol in human serum for application in pharmacokinetics
To determine metoprolol and its metabolite α-hydroxymetoprolol in human serum we validated a method on an LC system with an Exactive® Orbitrap mass spectrometer (Thermo Scientific) as detector and isotope-labelled metoprolol-d7 as internal standard. A simple sample preparation was used with water-ac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Betasciencepress Publishers
2017-06-01
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| Series: | Journal of Applied Bioanalysis |
| Subjects: | |
| Online Access: | https://doi.org/10.17145/jab.17.008 |