Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA
Human glutamate dehydrogenase isozymes (hGDH1 andhGDH2) have been known to be inhibited by palmitoyl-CoAwith a high affinity. In this study, we have performed the cassettemutagenesis at six different Cys residues (Cys59, Cys93,Cys119, Cys201, Cys274, and Cys323) to identify palmitoyl-CoA binding sit...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2012-12-01
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| Series: | BMB Reports |
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| Online Access: | http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTE0MTVAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMiU1RDEyMTIyNjE2MjRfJTI4NzA3LTcxMiUyOUJNQl8xMi0xNTYucGRm |