Uncovering Distinct Primary Vaccination-Dependent Profiles in Human <i>Bordetella Pertussis </i>Specific CD4+ T-Cell Responses Using a Novel Whole Blood Assay

Uncovering Distinct Primary Vaccination-Dependent Profiles in Human <i>Bordetella Pertussis </i>Specific CD4+ T-Cell Responses Using a Novel Whole Blood Assay

To advance research and development of improved pertussis vaccines, new immunoassays are needed to qualify the outcome of <i>Bordetella pertussis</i> (Bp) specific CD4+ T-cell differentiation. Here, we applied a recently developed whole blood assay to evaluate Bp specific CD4+ T-cell res...

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Bibliographic Details
Main Authors: Eleonora E. Lambert, Véronique Corbière, Jacqueline A. M. van Gaans-van den Brink, Maxime Duijst, Prashanna Balaji Venkatasubramanian, Elles Simonetti, Martijn Huynen, Dimitri D. Diavatopoulos, Pauline Versteegen, Guy A. M. Berbers, Françoise Mascart, Cécile A. C. M. van Els
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Vaccines
Subjects:
<i>Bordetella pertussis</i>
whole blood assay
CD4+ T-cells
Th polarization
Th cytokines
booster vaccination
Online Access:https://www.mdpi.com/2076-393X/8/2/225

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https://www.mdpi.com/2076-393X/8/2/225

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