Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment

Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment

Abstract Liver fibrosis (LF) is a dangerous clinical condition with no available treatment. Inflammation plays a critical role in LF progression. Glucocorticoid-induced leucine zipper (GILZ, encoded in mice by the Tsc22d3 gene) mimics many of the anti-inflammatory effects of glucocorticoids, but its...

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Bibliographic Details
Main Authors: Sara Flamini, Philipp Sergeev, Zenobio Viana de Barros, Tommaso Mello, Michele Biagioli, Musetta Paglialunga, Chiara Fiorucci, Tatiana Prikazchikova, Stefano Pagano, Andrea Gagliardi, Carlo Riccardi, Timofei Zatsepin, Graziella Migliorati, Oxana Bereshchenko, Stefano Bruscoli
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03704-w

Internet

https://doi.org/10.1038/s41419-021-03704-w

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