Design, synthesis and antitumor activity of C3/C3 bis-fluoroquonolones cross-linked with [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole

Design, synthesis and antitumor activity of C3/C3 bis-fluoroquonolones cross-linked with [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole

To contribute to the development of an efficient method for the conversion of antibacterial fluoroquinolones to antitumor fluoroquinolones, a series of C3/C3 bis-fluoroquinolone fused heterocycles cross-linked with a [1,2,4]-triazolo[3,4-b] [1,3,4]-thiadiazole core as a common bioisostere of two car...

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Bibliographic Details
Main Authors: Guo-qiang Hu, Yong Yang, Lei Yi, Guo-qiang Wang, Nan-nan Duan, Xiao-yi Wen, Tie-yao Cao, Song-qiang Xie, Wen-Long Huang
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Fluoroquinolone
Triazolothiadiazole
Synthesis
Antitumor evaluation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511000499

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http://www.sciencedirect.com/science/article/pii/S2211383511000499

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