The Presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection.

The Presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection.

The human cytomegalovirus (CMV) immune evasion protein, UL40, shares an identical peptide sequence with that found in the leader sequence of many human leukocyte antigen (HLA)-C alleles and when complexed with HLA-E, can modulate NK cell functions via interactions with the CD94-NKG2 receptors. Howev...

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Bibliographic Details
Main Authors: Lucy C Sullivan, Glen P Westall, Jacqueline M L Widjaja, Nicole A Mifsud, Thi H O Nguyen, Aislin C Meehan, Tom C Kotsimbos, Andrew G Brooks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4547726?pdf=render

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http://europepmc.org/articles/PMC4547726?pdf=render

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