Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Abstract Background Though accumulated evidence has demonstrated visceral organ involvement in acute graft-versus-host disease (aGVHD), how aGVHD influences the bone marrow (BM) niche and the reconstitution of hematopoiesis post-hematopoietic stem cell transplantation remains largely unknown. Method...

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Bibliographic Details
Main Authors: Li Ding, Hong-Mei Ning, Pei-Lin Li, Hong-Min Yan, Dong-Mei Han, Xiao-Li Zheng, Jing Liu, Ling Zhu, Mei Xue, Ning Mao, Zi-Kuan Guo, Heng Zhu, Heng-Xiang Wang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Stem Cell Research & Therapy
Subjects:
Acute graft versus host disease
Bone marrow niche
Mesenchymal stem cell
Stemness
Tumor necrosis factor-α
Online Access:http://link.springer.com/article/10.1186/s13287-020-01615-9

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http://link.springer.com/article/10.1186/s13287-020-01615-9

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