Alpha-synuclein mutations impair axonal regeneration in models of Parkinson´s disease

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson´s disease

The dopaminergic (DAergic) nigrostriatal tract has an intrinsic regenerative capacity which can be impaired in Parkinson’s disease (PD). Alpha-synuclein (aSyn) is a major pathogenic component in PD but its impact on DAergic axonal regeneration is largely unknown. In this study, we expressed pathogen...

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Bibliographic Details
Main Authors: Lars eTönges, Eva eSzegö, Patrizia eHause, Kim Ann Saal, Lars eTatenhorst, Jan Christoph Koch, Zara ed`Hedouville, Sebastian eKügler, Christoph eDohm, Mathias eBähr, Paul eLingor
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
alpha-Synuclein
axonal regeneration
rho-kinase
GAP-43
6-OHDA
A30P
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00239/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00239/full

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