Retinoblastoma discordance in families with twins

Retinoblastoma discordance in families with twins

Retinoblastoma has an increased inheritance risk of germline RB1 mutations in offspring and siblings, especially twins. Three families, each having one retinoblastoma-affected twin, were selected for genetic analysis and DNA profiling. Germline RB1 mutations were found in all probands. DNA profiling...

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Bibliographic Details
Main Authors: Aloysius Abraham, Kannan Thirumalairaj, Namrata Gaikwad, Veerappan Muthukkaruppan, Alla G Reddy, Kumarasamy Thangaraj, Usha Kim, Ayyasamy Vanniarajan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Indian Journal of Ophthalmology
Subjects:
DNA profiling
genetic analysis
Retinoblastoma 1 (RB1) gene
retinoblastoma
twins
Online Access:http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=3;spage=436;epage=439;aulast=Abraham

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http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=3;spage=436;epage=439;aulast=Abraham

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