A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open sta...

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Bibliographic Details
Main Authors: Neeti Ananthaswamy, Qianglin Fang, Wadad AlSalmi, Swati Jain, Zhenguo Chen, Thomas Klose, Yingyuan Sun, Yue Liu, Marthandan Mahalingam, Subhash Chand, Sodsai Tovanabutra, Merlin L. Robb, Michael G. Rossmann, Venigalla B. Rao
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08825-7

Internet

https://doi.org/10.1038/s41467-019-08825-7

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