Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19...

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Bibliographic Details
Main Authors: Sarah Alsharif, Pooja Sharma, Karina Bursch, Rachel Milliken, Van Lam, Arwa Fallatah, Thuc Phan, Meagan Collins, Priya Dohlman, Sarah Tiufekchiev, Georges Nehmetallah, Christopher B. Raub, Byung Min Chung
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Cell Adhesion & Migration
Subjects:
intermediate filaments
keratin
adherens junction
cell-cell adhesion
breast cancer
metastasis
cell migration
cell morphology
keratin 19
Online Access:http://dx.doi.org/10.1080/19336918.2020.1868694

Internet

http://dx.doi.org/10.1080/19336918.2020.1868694

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