Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

Bone disease severely affects the quality of life of over 70% of multiple myeloma (MM) patients, which daily experience pain, pathological fractures, mobility issues and an increased mortality. Recent data have highlighted the crucial role of the endoplasmic reticulum-associated unfolded protein res...

Full description

Bibliographic Details
Main Authors: Lavinia Raimondi, Angela De Luca, Simona Fontana, Nicola Amodio, Viviana Costa, Valeria Carina, Daniele Bellavia, Stefania Raimondo, Sergio Siragusa, Francesca Monteleone, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
multiple myeloma
bone disease
extracellular-vesicles
osteoclasts
UPR-related molecules
Online Access:https://www.mdpi.com/2072-6694/12/8/2167

Internet

https://www.mdpi.com/2072-6694/12/8/2167

Similar Items