Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivity is still under debate. Here, we probe the trans...

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Bibliographic Details
Main Authors: Adithya N Ananth, Ankur Mishra, Steffen Frey, Arvind Dwarkasing, Roderick Versloot, Erik van der Giessen, Dirk Görlich, Patrick Onck, Cees Dekker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Nuclear Pore Complex
FG-Nups
solid-state nanopores
selective barrier
Online Access:https://elifesciences.org/articles/31510

Internet

https://elifesciences.org/articles/31510

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