Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries.

Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries.

The sphingosine-1-phosphate (S1P) analog FTY720 exerts pleiotropic effects on the cardiovascular system and causes down-regulation of S1P receptors. Myogenic constriction is an important mechanism regulating resistance vessel function and is known to be modulated by S1P. Here we investigated myogeni...

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Bibliographic Details
Main Authors: Mahdi Hamidi Shishavan, Arash Bidadkosh, Saleh Yazdani, Sebastiaan Lambooy, Jacob van den Born, Hendrik Buikema, Robert H Henning, Leo E Deelman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5008781?pdf=render

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http://europepmc.org/articles/PMC5008781?pdf=render

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