Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation

Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation

Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell proliferation based on our related previous structu...

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Bibliographic Details
Main Authors: Kunal Kumar, Peng Wang, Ethan A. Swartz, Susmita Khamrui, Cody Secor, Michael B. Lazarus, Roberto Sanchez, Andrew F. Stewart, Robert J. DeVita
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
dual-specificity tyrosine-regulated kinases (DYRKs)
harmine
DYRK1A inhibitor
structure–activity relationship study
β-cell proliferation
diabetes
Online Access:https://www.mdpi.com/1420-3049/25/8/1983

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https://www.mdpi.com/1420-3049/25/8/1983

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