Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.
The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-11-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2065908?pdf=render |