The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding

The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding

The catalytic subunit E9 of the vaccinia virus DNA polymerase forms a functional polymerase holoenzyme by interacting with the heterodimeric processivity factor A20/D4. Here the authors present the structure of full-length E9 and show that an insertion within its palm domain binds A20, in a mode dif...

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Bibliographic Details
Main Authors: Nicolas Tarbouriech, Corinne Ducournau, Stephanie Hutin, Philippe J. Mas, Petr Man, Eric Forest, Darren J. Hart, Christophe N. Peyrefitte, Wim P. Burmeister, Frédéric Iseni
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01542-z

Internet

https://doi.org/10.1038/s41467-017-01542-z

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