Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.

Munc18-1 is an essential synaptic protein functioning during multiple stages of the exocytotic process including vesicle recruitment, docking and fusion. These functions require a number of distinct syntaxin-dependent interactions; however, Munc18-1 also regulates vesicle fusion via syntaxin-indepen...

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Bibliographic Details
Main Authors: Margaret E Graham, Gerald R Prescott, James R Johnson, Mathew Jones, Alice Walmesley, Lee P Haynes, Alan Morgan, Robert D Burgoyne, Jeff W Barclay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3061876?pdf=render

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http://europepmc.org/articles/PMC3061876?pdf=render

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