Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potential, although relevant adverse effects have limited their clinical use. Functionally selective KOPr agonists may activate, in a pathway-specific manner, G protein-mediated signaling, that produces antino...

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Bibliographic Details
Main Authors: Andrea Bedini, Lorenzo Di Cesare Mannelli, Laura Micheli, Monica Baiula, Gabriela Vaca, Rossella De Marco, Luca Gentilucci, Carla Ghelardini, Santi Spampinato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
kappa opioid receptor
functional selectivity
intracellular signaling
chemotherapy-induced neuropathic pain
antinociception
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00188/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00188/full

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