Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma. The present study examined acyclovir, reported as a low-affinity PNP inhibitor, for the...

Full description

Bibliographic Details
Main Authors: Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash
Format: Article
Language:English
Published: Mazandaran University of Medical Sciences 2019-04-01
Series:Pharmaceutical and Biomedical Research
Subjects:
purine nucleoside phosphorylase
halogen
acyclovir
analogs
t-cell lymphoma
molecular docking simulation
Online Access:http://pbr.mazums.ac.ir/article-1-252-en.html

Internet

http://pbr.mazums.ac.ir/article-1-252-en.html

Similar Items