Effects of a Buried Cysteine-To-Serine Mutation on Yeast Triosephosphate Isomerase Structure and Stability

Effects of a Buried Cysteine-To-Serine Mutation on Yeast Triosephosphate Isomerase Structure and Stability

All the members of the triosephosphate isomerase (TIM) family possess a cystein residue (Cys126) located near the catalytically essential Glu165. The evolutionarily conserved Cys126, however, does not seem to play a significant role in the catalytic activity. On the other hand, substitution of this...

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Bibliographic Details
Main Authors: Adela Rodríguez-Romero, Andrés Hernández-Arana, Edith González-Mondragón, Alejandra Hernández-Santoyo, César A. Reyes-López, Lenin Domínguez-Ramírez
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
crystal structure
molecular dynamics
<em> Saccharomyces cerevisiae</em>
stability
triosephosphate isomerase
Online Access:http://www.mdpi.com/1422-0067/13/8/10010

Internet

http://www.mdpi.com/1422-0067/13/8/10010

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